Bicarbonate as a potentiator for antimicrobial agents
AssigneeMcMaster University
InventorsEric Brown, Maya Farha, Craig MacNair
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Abstract
Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.
Claims18
A method for inhibiting the growth of a bacterium, comprising contacting the bacterium with an effective amount of (i) bicarbonate and (ii) an antimicrobial agent, wherein the antimicrobial agent is azithromycin, and the effective amount of the bicarbonate is a concentration of greater than 150 mM.
A kit comprising i) a first bicarbonate composition and ii) a second antimicrobial composition, wherein the first composition comprises bicarbonate in an amount of greater than 150 mM and a pharmaceutically acceptable carrier, and the second composition comprises an antimicrobial agent azithromycin.
Dependencies are inferred from the claim text.