Polymeric carriers for delivery of therapeutic agents
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsSong Li, Yixian Huang, Haozhe Huang
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Abstract
A polymer includes a hydrophobic polymer backbone, a first plurality of pendant groups attached to the hydrophobic polymer backbone and including a first moiety including at least one group selected for ionic interaction with a second therapeutic agent, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer. The first moiety is attached via a labile bond and is released in vivo from the polymer to provide a biologically or therapeutically active form of a first therapeutic compounds.
Claims25
A polymer, comprising:
- a hydrophobic polymer backbone,
- a first plurality of pendant groups attached to the hydrophobic polymer backbone and comprising a moiety attached to the hydrophobic polymer backbone via a bond which is labile in vivo to release a first therapeutic compound which is a COX inhibitor, the moiety comprising a group to ionically interact with a second therapeutic compound, different from the first therapeutic compound, and
- a second plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one hydrophilic polymer.
A formulation, comprising:
- a plurality of polymers comprising a hydrophobic polymer backbone, a first plurality of pendant groups attached to the hydrophobic polymer backbone and comprising a moiety attached to the hydrophobic polymer backbone via a bond which is labile in vivo to release as a first therapeutic compound which is a COX inhibitor and a second plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one hydrophilic polymer and a second therapeutic compound, different from the first therapeutic compound, the moiety comprising a group to ionically interact with a group of the second therapeutic compound.
Dependencies are inferred from the claim text.