Compounds for treatment of hemolysis-and inflammasome-associated diseases
AssigneeNew York Blood Center, Inc.
InventorsHui Zhong, Karina Yazdanbakhsh
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Abstract
Disclosed herein are methods of treating a complication of a hemolysis and/or an inflammasome activation-associated disease comprising administering to a patient in need thereof quinine, or a derivative or salt thereof, or the combination of quinine and hemin. Also disclosed is a method of reducing alloimmunization in chronically transfused subjects, comprising administering to a patient in need thereof a therapeutically effective dose of quinine.
Claims15
A method of treating a vaso-occlusive crisis in a patient having sickle cell disease, comprising administering to a patient in need thereof a therapeutically effective dose of quinine base or quinine salt or a combination of quinine base or quinine salt and hemin.
A method of treating a vaso-occlusive crisis in a patient having sickle cell disease, comprising administering to a patient in need thereof a therapeutically effective dose of a combination of quinine base or quinine salt and hemin, wherein the combination of quinine base or quinine salt and hemin is in a dose effective in inhibiting NLRP3 inflammasome pathway in a patient.
Dependencies are inferred from the claim text.