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US 12,678,430 B2Granted
Compositions and methods for the treatment of liver disorders
AssigneeViking Therapeutics, Inc.
InventorsBrian Lian, Geoffrey E. Barker, Kader Yagiz, Maureen Barnes, Erland Stevens
Life of this patent
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Abstract
The present disclosure is directed to FXR agonists, pharmaceutical compositions thereof, and methods of using the same for preventing, treating, or ameliorating fatty liver diseases such as steatosis, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis, either alone or in combination with thyroid receptor agonists.
Claims20
A compound of Formula (II):
- or a pharmaceutically acceptable salt thereof;
- wherein
- R1 is selected from the group consisting of:
- C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl, or 5-10 membered heterocyclyl, each of which is optionally substituted with 1-3 R1A;
- R2 is halogen, C1-6 alkyl, haloC1-6 alkyl, C1-6 alkoxy, haloC1-6 alkoxy, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl, or 5-10 membered heterocyclyl each of which is optionally substituted with 1-3 R2A;
- G is selected from the group consisting of:
- C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl, or 5-10 membered heterocyclyl, each of which is optionally substituted with 1-3 RG;
- R3 is —P(═O)(X)(Y) or 5-10 membered heteroaryl containing 1-2 heteroatoms selected from N, O and S optionally substituted with 1-2 R3A independently selected from halogen, —OR5, C1-6 alkyl, haloC1-6 alkyl, haloC1-6 alkoxy, or C3-10 cycloalkyl;
- each R1A is independently selected from the group consisting of halogen, C1-6 alkyl, haloC1-6 alkyl, C1-6 alkoxy, haloC1-6 alkoxy, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl, and 5-10 membered heterocyclyl;
- each R2A is independently selected from the group consisting of halogen, C1-6 alkyl, haloC1-6 alkyl, C1-6 alkoxy, haloC1-6 alkoxy, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl, and 5-10 membered heterocyclyl;
- each RG is independently selected from the group consisting of halogen, C1-6 alkyl, haloC1-6 alkyl, C1-6 alkoxy, and haloC1-6 alkoxy;
- X and Y are each independently —OR4, NR5R6, C1-6 alkyl, or haloC1-6 alkyl;
- each R4 is independently hydrogen, C1-6 alkyl, or haloC1-6 alkyl;
- each R5 is independently hydrogen or C1-6 alkyl;
- and
- each R6 is independently hydrogen or C1-6 alkyl.
13 more elements
Dependencies are inferred from the claim text.