Synergistic composition for inhibiting vascular calcification
AssigneeCelagenex Research (India) Pvt. Ltd.
InventorsRajaram Samant, Rajendra Prasad T., Jotiram Palkar
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Abstract
The invention disclosed herein relates to synergistic bioactive compositions for inhibiting vascular calcification. Particularly, the present invention relates to exogenous blend of magnesium 2-acetylamino ethane sulfonic acid and 2-methyl-4-aminomethyl-5-hydroxymethyl-3-pyridinol and salts thereof which are present in the weight ratio of 1:0.002 to 1:1.8 along with pharmaceutically acceptable excipients. More particularly, the synergistic composition is useful for treating cardiovascular diseases and renal vascular diseases.
Claims5
A synergistic bioactive composition for inhibiting vascular calcification, comprising a therapeutically active exogenous combination of an effective amount of magnesium 2-acetylamino ethane sulfonic acid and 2-methyl-4-aminomethyl-5-hydroxymethyl-3-pyridinol or salts thereof, along with at least one pharmaceutically acceptable excipient wherein the magnesium 2-acetylamino ethane sulfonic acid and 2-methyl-4-aminomethyl-5-hydroxymethyl-3-pyridinol or salts thereof are present in a weight ratio of 1:0.002 to 1:1.8 along with the at least one pharmaceutically acceptable excipient, and wherein the magnesium 2-acetylamino ethane sulfonic acid is white crystalline and present in a range of 25% to 99% by weight of the total composition and the 2-methyl-4-aminomethyl-5-hydroxymethyl-3-pyridinol salt is white crystalline and present in a range of 0.1% to 60% by weight of the total composition.
Dependencies are inferred from the claim text.