Back to results
US 12,678,419 B2Granted
Compounds
AssigneeSitryx Therapeutics Limited
InventorsMatthew Colin Thor Fyfe, Barry John Teobald
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: wherein RA1, RA2, RA3, RB, RC, RD, m, n and p are as defined herein.
Claims15
A compound of formula (I):
- wherein:
- RA1 is selected from the group consisting of H, halo, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, C1-4haloalkoxy, —SC1-4alkyl, —SC1-4haloalkyl and SF5;
- RA2 is selected from the group consisting of halo, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy and C1-4haloalkoxy;
- RA3 is C1-2alkyl;
- m is 0, 1 or 2;
- n is 1 or 2;
- p is 0 or 1;
- and
- RB is selected from the group consisting of CH2COOH, CH2CH2COOH, CH2tetrazolyl and CH2CH2tetrazolyl, wherein RB is optionally substituted on an available carbon atom by one or more RB1 wherein RB1 is selected from the group consisting of difluoromethyl, trifluoromethyl and methyl, and/or wherein RB is optionally substituted by two RB1 groups, attached to the same carbon atom, that are joined to form a C3-6 cycloalkyl or a 4-6-membered heterocyclyl ring;
- and
- RC and RD are each independently H, C1-2 alkyl, hydroxy, methoxy or fluoro;
- or a pharmaceutically acceptable salt and/or solvate thereof.
9 more elements
Dependencies are inferred from the claim text.