Respiratory syncytial virus (RSV) polyanhydride nanoparticle vaccine
AssigneeUniversity of Iowa Research Foundation
InventorsSteven M. Varga, Kevin L. Legge
Life of this patent
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Abstract
Disclosed are compositions and methods for vaccinating susceptible individuals against infection by respiratory syncytial virus (RSV). The disclosed compositions include vaccine compositions comprising an effective amount of respiratory syncytial virus (RSV) F protein in a pre-fusion stabilized form and/or M protein incorporated into biodegradable polyanhydride polymer particles for inducing an immune response against RSV. The vaccine compositions also may include a suitable adjuvant.
Claims20
A vaccine composition comprising
- a) an effective amount of respiratory syncytial virus (RSV) F protein in a pre-fusion stabilized form and RSV M protein,
- b) a CpG oligonucleotide, and
- c) biodegradable polyanhydride polymer particles formed from a 1,ω-bis(p-carboxyphenoxy)(C2-C12)alkane, a 1,ω-bis(p-carboxyphenoxy)(C2-C12)dioxa-alkane, and a (C5-C20)alkanoic diacid,
- wherein the pre-fusion stabilized RSV F protein and RSV M protein, and the CpG oligonucleotide are incorporated into the biodegradable polyanhydride polymer particles for inducing an immune response against RSV.
A method comprising administering a vaccine composition to a subject who is at risk for infection by RSV, the vaccine composition comprising:
- a) an effective amount of respiratory syncytial virus (RSV) F protein in a pre-fusion stabilized form,
- b) a CpG oligonucleotide, and
- c) biodegradable polvanhydride polymer particle formed from a 1,ω-bis(p-carboxyphenoxy)(C2-C12)alkane, a 1,ω-bis(p-carboxyphenoxy)(C2-C12)dioxa-alkane, and a (C5-C20)alkanoic diacid,
- wherein the pre-fusion stabilized RSV F protein and the CpG oligonucleotide are incorporated into the biodegradable polyanhydride polymer particles, wherein the vaccine composition is administered at least once to the subject, and wherein administration of the vaccine composition induces an immune response against RSV in the subject that protects against infection by RSV and the protection is effective upon exposure to RSV.
Dependencies are inferred from the claim text.