Dermatological compositions and use thereof

A method of treating a soft tissue defect, the method comprising the step of injecting or implanting to a subject in need thereof an effective amount of a dermatological composition comprising at least one amphiphilic peptide comprising alternating hydrophobic/hydrophilic amino acid residues, or a derivative or a salt thereof, wherein the peptide comprises 1-20 pairs of hydrophobic-hydrophilic alternating amino acid residues, wherein the hydrophilic amino acid residue is selected from the group consisting of Glu, Asp, Tyr, Ser, Thr, Ser(PO4), Thr(PO4), and Tyr(PO4), and the hydrophobic amino acid residue is selected from the group consisting of Phe, Leu, Ile, Val, Trp, and Ala, and wherein said peptide has no more than 10% positively charged amino acid residues, and a dermatologically acceptable carrier, wherein the dermatological composition is a soft tissue filler composition.

A method for treating an epidermal condition related to aging selected from the group consisting of elastosis, atrophy of the skin, fine lines, wrinkles, enlarged pores, hyperpigmentation, hypopigmentation, sagging skin, rough skin, and dry skin, or a method for treating a skin condition selected from the group consisting of cuts, wounds, burns, insect bites, jellyfish stings, a rash, skin allergic responses, and skin lesions, the method comprising the step of locally administering to a subject in need thereof an effective amount of a dermatological composition comprising at least one amphiphilic peptide comprising alternating hydrophobic/hydrophilic amino acid residues, or a derivative or a salt thereof, wherein the peptide comprises 1-20 pairs of hydrophobic-hydrophilic alternating amino acid residues, wherein the hydrophilic amino acid residue is selected from the group consisting of Glu, Asp, Tyr, Ser, Thr, Ser(PO4), Thr(PO4), and Tyr(PO4), and the hydrophobic amino acid residue is selected from the group consisting of Phe, Leu, Ile, Val, Trp, and Ala, and wherein said peptide has no more than 10% positively charged amino acid residues, and a dermatologically acceptable carrier, wherein the dermatological composition is a cosmetic composition.