Sensor assembly
AssigneeAnalog Devices International Unlimited Company
InventorHelen Berney
Life of this patent
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Abstract
The present disclosure provides systems and method for determining a property of an analyte in a sample, the systems and methods use a sensor assembly comprising a sensing layer provided with through holes and a capture species configured to specifically bind with the analyte. The capture species is located adjacent and/or in the through holes such that analyte bound to the capture species can interact with the through holes of the sensing layer so as to alter the impedimetric property of the sensing layer. The sensing element provides a measurement signal which is indicative of an impedimetric property of the sensing layer and/or the sensing element comprises an IDE with at least a part of the sensing layer provided between electrodes of the IDE.
Claims20
A system for determining a property of an analyte in a sample, the system comprising:
- a sensor assembly comprising:
- a fluid chamber for receiving a sample;
- and
- a sensing element comprising:
- a sensing layer, the sensing layer comprising an upper surface and a lower surface and a plurality of through holes, each of the through holes extending from the upper surface to the lower surface;
- and
- capture species configured to specifically bind with analyte provided on the sensing layer;
- and
- a property determination unit configured to determine the property of the analyte,
- wherein the sensing element is arranged in the fluid chamber such that sample can reside above the upper surface, reside below the lower surface and pass through the through holes in the sensing layer;
- wherein the sensing element provides a measurement signal indicative of an impedimetric property of the sensing layer;
- wherein the capture species are located adjacent and/or in the through holes such that analyte bound to the capture species can interact with the through holes of the sensing layer so as to alter the impedimetric property of the sensing layer;
- and
- wherein the property determination unit is configured to determine the property of the analyte based on the impedimetric property of the sensing layer indicated by the measurement signal.
A system for determining a property of an analyte in a sample, the system comprising:
- A sensor assembly comprising:
- A fluid chamber for receiving a sample;
- A sensing element, the sensing element comprising:
- An interdigitated electrode (IDE) comprising a first electrode and a second electrode, the first and second electrodes arranged in an interdigitated configuration;
- A sensing layer arranged at least in part between the first electrode and the second electrode of the IDE, the sensing layer comprising an upper surface and a lower surface and a plurality of through holes, each of the through holes extending from the upper surface to the lower surface;
- and
- Capture species configured to specifically bind with the analyte provided on the sensing layer,
- Wherein the capture species are located adjacent and/or in the through holes such that analyte bound to the capture species can interact with the through holes of the sensing layer;
- and
- Wherein the sensing element provides a measurement signal indicative of the interaction of the sensing element with the analyte;
- and
- Wherein the sensing element is arranged in the fluid chamber such that sample can reside above the upper surface, reside below the lower surface and pass through the through holes in the sensing layer.
A method for determining a property of an analyte in a sample, the method comprising:
- providing a sensor assembly, the sensor assembly comprising:
- a fluid chamber for receiving a sample;
- and
- a sensing element comprising:
- a sensing layer, the sensing layer comprising an upper surface and a lower surface and a plurality of through holes, each of the through holes extending from the upper surface to the lower surface, wherein the sensing element is arranged in the fluid chamber such that sample can reside above the upper surface, reside below the lower surface and pass through the through holes in the sensing layer;
- and
- capture species configured to specifically bind with analyte provided on the sensing layer, wherein the capture species are located adjacent and/or the through holes such that analyte bound to the capture species can interact with the through holes of the sensing layer so as to alter an impedimetric property of the sensing layer;
- providing a sample to the sensing element, wherein at least a portion of analyte in the sample binds to the capture species to form specifically-bound analyte;
- obtaining a measurement signal indicative of the impedimetric property of the sensing layer from the sensing element;
- and
- determining the property of the analyte based on the impedimetric property of the sensing layer indicated by the measurement signal.
Dependencies are inferred from the claim text.