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US 12,674,807 B2Granted
Systems, methods and compositions for analysis of proteoforms
AssigneeNautilus Subsidiary, Inc.
InventorsParag Mallick, Jarrett D. Egertson, Gregory Kapp, Kara Juneau, Vivekananda Budamagunta, Sanjib Guha, James Henry Joly, Steven Tan, Zhengjian Zhang, Maryam Jouzi
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Abstract
Methods, reagents, kits and systems for analyzing different proteoforms of proteins of interest are provided. The provided methods, systems, etc. provide detection, characterization and quantitation of proteoforms for different biologically relevant proteins for monitoring and characterizing biological processes.
Claims23
A method of analyzing proteins in a first sample, comprising:
- providing a population of individual protein molecules from the first sample, wherein said individual protein molecules are immobilized upon one or more solid supports and are individually addressable, and wherein the population of individual protein molecules comprises a plurality of individual molecules of a Tau protein;
- and
- identifying a plurality of proteoforms of the Tau protein in the first sample by identifying the proteoform represented by each of the plurality of individual molecules of Tau protein on the one or more solid supports based upon identification of a presence or absence of at least 3 different modifications within each of the individual molecules of the Tau protein.
Dependencies are inferred from the claim text.