Systems and methods for electrospray using chromatographic columns with conducting or semiconducting stationary phases

A method for reducing electro-chromatographic effects in an electrospray system, comprising:

• flowing a fluid sample from a first pre-column fluid junction to a first end of a chromatographic column, the chromatographic column including a conductive or semi-conductive stationary phase disposed between the first end and a second end of the chromatographic column;
• separating analytes within the fluid sample using the chromatographic column;
• outputting the separated fluid sample from the second end of the chromatographic column to a first fluid port of a post-column fluid union, the post-column fluid union having a second fluid port connected to an electrospray emitter;
• and
• applying an equipotential voltage in a range of +1 to +10 kilovolts or in a range of −1 to −10 kilovolts at both the first pre-column fluid junction and at the post-column fluid union using an electrical conductor in electrical contact with the first pre-column fluid junction and the post-column fluid union.