Methods and compositions for use of mitochondrial therapies to improve female reproductive potential
AssigneeNortheastern University
InventorsJonathan L. Tilly, Dori Woods
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Abstract
Disclosed are methods for increasing the fertilization rate of an oocyte in a granulosa cell-oocyte complex, and/or the success rate of in-vitro fertilization by using mitochondrial therapies. Also disclosed are methods of identifying compounds for fertility treatment.
Claims19
A method of increasing the fertilization rate of an oocyte, wherein the oocyte is in a granulosa cell-oocyte complex, the method comprising transferring a composition of mitochondria into the granulosa cells, wherein the transferred mitochondria have a higher mitochondrial membrane potential (MMP) than the mitochondria in the granulosa cells.
A method of in vitro fertilization, the method comprising incubating a composition of mitochondria with granulosa cells, wherein the granulosa cells are in a granulosa cell-oocyte complex;
- and fertilizing the oocyte in vitro to form a zygote, wherein the incubated mitochondria have a higher mitochondrial membrane potential (MMP) than the mitochondria in the granulosa cells.
Dependencies are inferred from the claim text.