Back to results
US 12,674,170 B2Granted
Aptamer for IL-21 and use thereof
AssigneeRibomic Inc.
InventorsKazuteru Aoki, Marie Mitsui
Life of this patent
Estimating the term…
Abstract
The present invention provides an aptamer that binds to IL-21, an aptamer that binds to IL-21 and inhibits the binding of IL-21 and a receptor thereof, and an aptamer that binds to IL-21 and contains a nucleotide sequence represented by the formula (1): CGRYKACY wherein R is A or G, Y is C or U, and K is G or U.
Claims7
An aptamer comprising the nucleotide sequence of SEQ ID NOs:
- 1-5, 7, 20-29, or 31-43 provided that uracil (U) is optionally thymine (T),
- wherein the nucleotide sequence of SEQ ID NOs:
- 1-5, 7, 20-29, or 31-43 is represented by the following formulas (1) to (3):
- formula (1) is CGRYKACY,
- formula (2) is CCKYC,
- formula (3) is GYMCG,
- wherein formulas (1) to (3) are arranged to comprise the order of formula (2), formula (1), and formula (3) from the 5′-terminal side,
- wherein R is A or G, Y is Cor U, K is G or U, and M is A or C, and
- wherein the aptamer binds to interleukin-21 and inhibits binding between the interleukin-21 and a interleukin-21 receptor.
6 more elements
Dependencies are inferred from the claim text.