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US 12,674,163 B2Granted
Comb shaped antivirals ending with or without chain terminating bases
OwnerAhmed Ibrahim Mohamed Ibrahiminventor
Life of this patent
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Abstract
Modified antisense mucleic acid molecules ending with or without chain terminating bases targeting the HIV-1 viral genomic RNA 3′ LTR region, and uses thereof for inhibiting HIV-1 replication and infection, are disclosed. The antisense mucleic acid molecules more specifically target a sequence corresponding to about nucleotide 9628 to about nucleotide 9642 of HIV-1 clone pNL4-3.
Claims12
Antisense nucleic acid molecules directed against a sequence corresponding to nucleotide 9628 to nucleotide 9642 of HIV-1 clone pNL4-3 ending with or without a 3′ terminal ddC and comprising one of the following sequences (I) or (II):
- (I) 5′-A*fC*GG*GfC*AfC*AfC*AC*T*+A*C-3′ (SEQ ID NO:
- 1)
- (II) 5′-A*fC*GG*GfC*AfC*AfC*AC*T*+A*[ddC]-3′ (SEQ ID NO:
- 2);
- wherein “+N” denotes a bridged nucleic acid nucleotide wherein “N” is “A,” “C,” “G” or “T”, “*” denotes a phosphorothioate linkage, “fN” denotes a 2′-fluoro ribonucleotide, and “[ddC]” denotes a 2′,3′-dideoxycytidine at the 3′ terminus.
2 more elements
Dependencies are inferred from the claim text.