Targeted chondroitinase ABC fusion proteins and complexes thereof
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsGregory Allan Hudalla, Benjamin G. Keselowsky, Dillon T. Seroski, Shaheen A. Farhadi, Christine E. Schmidt, Nikunj Kumar Agrawal
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Abstract
Described herein are targeted ChABC fusion proteins, complexes thereof, and uses thereof. The targeted ChABC fusion proteins can include a ChABC polypeptide that can be linked to a Gal-3 polypeptide. Monomer targeted ChABC fusion proteins can form homogeneous or heterogeneous complexes. The targeted ChABC fusion proteins and complexes thereof can be formulated as pharmaceutical formulations. The targeted ChABC fusion proteins, complexes thereof, and formulations thereof can be administered to a subject in need thereof.
Claims12
A targeted effector fusion protein comprising a polypeptide sequence that is identical to any one of SEQ ID NOs:
- 15-16.
Dependencies are inferred from the claim text.