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US 12,674,153 B2Granted
ACE2 muteins and methods of using the same
AssigneeEmmune, Inc.
InventorsCharles C. Bailey, Michael D. Alpert
Life of this patent
Estimating the term…
Abstract
The invention relates generally to non-naturally occurring ACE2 proteins and their use in the treatment of coronavirus infection.
Claims19
A fusion protein comprising a human angiotensin-converting enzyme 2 (ACE2) mutein and an antibody Fc domain, wherein the human ACE2 mutein comprises an amino acid sequence at least 80% identical to amino acids 19-615 of wild-type human ACE2 (SEQ ID NO:
- 1), wherein the fusion protein has a melting temperature of at least 60° C. in a differential scanning fluorimetry (DSF) assay, and wherein the ACE2 mutein is not identical to a wild-type ACE2 of a non-human animal.
Dependencies are inferred from the claim text.