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US 12,674,142 B2Granted
Hydrogel compositions and methods of use thereof
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsSarah Heilshorn, Riley Suhar, Daniel Hunt
Life of this patent
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Abstract
A two-component hydrogel matrix system is provided, which system is useful in a variety of cell growth uses, including without limitation three-dimensional culture systems. The components comprise modified hyaluronic acid (HA); and modified elastin-like proteins (ELP). Variables of HELP, including for example, matrix stiffness, matrix stress relaxation rate, and cell-adhesive-ligand concentration, can be independently and quantitatively specified.
Claims20
A two-component hydrogel matrix system comprising:
- a first component comprising a defined ratio of hyaluronic acid (HA) modified to comprise a pendant reactant group benzaldehyde;
- and a second component comprising an elastin-like protein (ELP) modified to comprise a pendant reactant group hydrazine group;
- wherein cross-links between the first component and the second component are formed to generate a hydrogel upon mixing.
Dependencies are inferred from the claim text.