Cluster airlift bioreactor

A bioreactor, including:

• a liquid;
• one or more sensors;
• a plurality of spargers;
• a plurality of vertical circulation loops, wherein each of the plurality of vertical circulation loops is associated with one or more of the plurality of spargers;
• a controller coupled to the plurality of spargers and the one or more sensors,
• wherein the controller is configured to:
• determine that a reading associated with the bioreactor is not at a setpoint;
• adjust a sparging rate associated with at least one of the plurality of spargers responsive to gas sparging or a liquid additive being introduced to the bioreactor, wherein the sparging rate associated with the at least one of the plurality of spargers is adjusted from a first sparging rate to a second sparging rate;
• and
• in response to the reading associated with the bioreactor being consistent and at the setpoint, modify the sparging rate associated with the at least one of the plurality of spargers from the second sparging rate to the first sparging rate.