Branched type hetero monodispersed polyethylene glycol, production method thereof, and conjugate thereof
AssigneesTokyo Institute of Technology, Nof Corporation
InventorsKazushi Kinbara, Tomoki Uruga, Tomoyuki Ohtake
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Abstract
An intermediate for production of a branched type hetero monodispersed polyethylene glycol which is represented by formula (2), the intermediate being represented by formula (3) or (40): where X1, L1, L3, Y1, Y2, and n are as defined herein.
Claims2
An intermediate for production of a branched type hetero monodispersed polyethylene glycol which is represented by formula (2), the intermediate being represented by formula (3):
- in formula (2),
- X1 and Y1 each represents an atomic group containing at least a functional group capable of reacting with a functional group present in a biofunctional molecule to form a covalent bond, provided that the functional group contained in the atomic group X1 and the functional group contained in the atomic group Y1 are different from each other,
- n is an integer of 6 to 12,
- L1 represents a single bond or a divalent organic group, and
- L3 represents a single bond, —L4—(CH2)m1—or —L4—(CH2)m2—L5—(CH2)m3—, L4 represents any of an ether bond, an amide bond and a urethane bond, L5 represents an amide bond or a urethane bond, and m1, m2 and m3 each independently represents an integer of 1 to 5,
- in formula (3),
- n represents an integer of 6 to 12, and
- Y2 represents —NH2 or —O—(CH2)m4—NH2, and m4 represents an integer of 1 to 5.
An intermediate for production of a branched type hetero monodispersed polyethylene glycol which is represented by formula (2), the intermediate being represented by formula (40):
- in formula (2),
- X1 and Y1 each represents an atomic group containing at least a functional group capable of reacting with a functional group present in a biofunctional molecule to form a covalent bond, provided that the functional group contained in the atomic group X1 and the functional group contained in the atomic group Y1 are different from each other,
- n is an integer of 6 to 12,
- L1 represents a single bond or a divalent organic group, and
- L3 represents a single bond, —L4—(CH2)m1— or —L4—(CH2)m2—L5—(CH2)m3—, L4 represents any of an ether bond, an amide bond and a urethane bond, L5 represents an amide bond or a urethane bond, and m1, m2 and m3 each independently represents an integer of 1 to 5,
- in formula (40),
- n represents an integer of 6 to 12, and
- Y2 represents —NH2 or —O—(CH2)m4—NH2, and m4 represents an integer of 1 to 5.
Dependencies are inferred from the claim text.