Polymeric biomaterials derived from phenolic monomers and their medical uses
AssigneeRutgers, The State University of New Jersey
InventorsJoachim B. Kohn, Durgadas Bolikal
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Abstract
The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.
Claims8
A biocompatible copolymer consisting of diphenolic backbone recurring units consisting of diphenolic recurring units selected from the group consisting of diphenolic recurring units of formula:
- wherein:
- y1 and y2 are independently 0, 1, 2, 3, or 4;
- m and n are each independently an integer in the range of 1 to 12;
- X1 and X2, at each occurrence, are each independently bromine (Br) or iodine (I);
- L1 is selected from the group consisting of a bond and —R4—C(O)—O—;
- R4 is selected from the group consisting of a bond, unsubstituted C1-C30 alkyl, unsubstituted C2-C30 alkenyl, unsubstituted C2-C30 alkynyl, unsubstituted C1-C30 heteroalkyl, unsubstituted C2-C30 heteroalkenyl, unsubstituted C2-C30 heteroalkynyl, unsubstituted C6-C30 aryl, unsubstituted C7-C30 alkylaryl, unsubstituted C8-C30 alkenylaryl, unsubstituted C8-C30 alkynylaryl, and unsubstituted C2-C30 heteroaryl;
- and
- L4 is a linking group selected from the group consisting of a bond and optionally substituted phenoxy of formula —C6H4—O—;
- wherein the bromine or iodine substitution is in the backbone of the copolymer;
- and
- wherein the copolymer is a condensation copolymer;
- L2 is a bond or —R8—C(O)—;
- and
- R8 is selected from the group consisting of a bond, unsubstituted C1-C30 alkylene, unsubstituted C2-C30 alkenylene, unsubstituted C2-C30 alkynylene, unsubstituted C1-C30 heteroalkylene, unsubstituted C2-C30 heteroalkenylene, unsubstituted C2-C30 heteroalkynylene, unsubstituted C7-C30 heteroalkylarylene, unsubstituted C8-C30 heteroalkenylarylene, unsubstituted C8-C30 heteroalkynylarylene, unsubstituted C7-C30 alkylarylene, unsubstituted C8-C30 alkenylarylene, unsubstituted C8-C30 alkynylarylene, and unsubstituted C2-C30 heteroarylene.
Dependencies are inferred from the claim text.