Alkylated cyclodextrin compositions and processes for preparing and using the same

A process for preparing an alkylated cyclodextrin composition, wherein the alkylated cyclodextrin is a compound having the structure

• wherein R is —H or —(CH2)4—SO3−Na+, and the average degree of substitution with —(CH2)4—SO3−Na+ is from 6 to 7.1;
• the process comprising:
• (a) mixing a cyclodextrin with an alkylating agent to form a reaction milieu comprising an alkylated cyclodextrin;
• (b) conducting one or more separations to form a partially purified solution comprising the alkylated cyclodextrin;
• (c) preparing an activated carbon comprising the step of subjecting the activated carbon to a carbon washing process comprising adding a portion of the partially purified solution comprising the alkylated cyclodextrin to the carbon, soaking the carbon in the partially purified solution for at least 30 minutes, and subsequently eluting and discarding the partially purified solution, and wherein the activated carbon is subsequently subjected to a washing process comprising adding water to the carbon and eluting the water, wherein the eluted wash water has a residual conductivity of 10 μS/cm or less;
• and
• (d) treating the remaining partially purified solution with the activated carbon prepared in step (c) to produce a final purified alkylated cyclodextrin composition;
• wherein the final purified alkylated cyclodextrin composition comprises less than 0.01% (w/w) of a chloride.