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US 12,673,977 B2Granted
Heterologous proteins with axonemal proteins
AssigneesThe Regents of the University of California, The Texas A&M University System
InventorsWallace F. Marshall, Hongmin Qin
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Abstract
Provided herein are compositions and methods for the production of heterologous proteins in a cell including axonemes. The cells include a nucleic acid encoding a fusion protein expressed in the axoneme. The fusion protein includes an axonemal protein linked to a heterologous protein, and the fusion protein provides axonemal function to the cell.
Claims7
An algal cell comprising:
- a nucleic acid encoding a fusion protein, wherein the fusion protein comprises an axonemal protein linked to a heterologous protein through an enzyme cleavable linker, wherein said axonemal protein is FAP20, and wherein the heterologous protein is an enzyme.
A plurality of algal cells wherein each algal cell comprises:
- a nucleic acid encoding a fusion protein, wherein the fusion protein comprises an axonemal protein linked to a heterologous protein through an enzyme cleavable linker, wherein said axonemal protein is FAP20, and wherein the heterologous protein is an enzyme.
A recombinant protein comprising:
- a. an algal axonemal protein, and
- b. a heterologous protein;
- wherein the axonemal protein is linked to the heterologous protein through an enzyme cleavable linker;
- wherein said axonemal protein is FAP20;
- and wherein the heterologous protein is an enzyme.
2 more elements
Dependencies are inferred from the claim text.