Cyclic peptide, cell scaffold material, cell separating material, and medium
AssigneeFUJIFILM Corporation
InventorKoichi Minami
Life of this patent
Estimating the term…
Abstract
There is provided a cyclic peptide containing a cyclic segment containing an RGD sequence and having 8 to 14 amino acid residues. A thioether bond is formed between an amino acid residue Xa located on a most N-terminal side of the cyclic segment and an amino acid residue Xb located on a most C-terminal side of the cyclic segment. However, in a case where one of the amino acid residue Xa and the amino acid residue Xb is a cysteine residue, an α carbon of the other amino acid residue of the amino acid residue Xa and the amino acid residue Xb is separated from a sulfur atom of the cysteine residue by five or more atoms.
Claims14
A cyclic peptide comprising:
- a cyclic segment comprising an RGD sequence and having 8 to 14 amino acid residues,
- a thioether bond being formed between an amino acid residue Xa located on a most N-terminal side of the cyclic segment and an amino acid residue Xb located on a most C-terminal side of the cyclic segment,
- wherein one of the amino acid residue Xa and the amino acid residue Xb is a 2-amino-4-acetylamino-butanoic acid residue, an N-δ-acetyl-ornithine residue, or an N-ε-acetyl-lysine residue, and
- the other one of the amino acid residue Xa and the amino acid residue Xb is an L-homocysteine residue or a D-homocysteine residue,
- wherein the α carbon of the 2-amino-4-acetylamino-butanoic acid residue, the N-δ-acetyl-ornithine residue, or the N-ε-acetyl-lysine residue is separated from the sulfur atom of the L-homocysteine residue or the D-homocysteine residue by five or more atoms, and
- wherein the cyclic segment comprises an amino acid sequence having 80% or more sequence identity to the amino acid sequence IPRGDNFR (SEQ ID NO:
- 1), IPRGDSFA (SEQ ID NO:
- 170), VPRGDTFA (SEQ ID NO:
- 171), or TPRGDTFA (SEQ ID NO:
- 172).
Dependencies are inferred from the claim text.