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US 12,673,969 B2Granted
CD73 inhibitors and pharmaceutical uses thereof
AssigneeRisen (Suzhou) Pharma Tech Co., Ltd.
InventorsJiasheng Lu, Gang Chen, Qiguo Zhang, Xianqi Kong, Dawei Chen, Chuanhao Huang, Xingwu Zhu, Yuhua Zhang
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Abstract
CD73 (also known as ecto-5′-nucleotidase) inhibitor compounds are provided, as well as compositions and uses thereof for treating or preventing CD73-associated or related diseases, disorders and conditions, including cancer- and immune-related disorders. CD73 inhibitor compounds include compounds having the structure set forth in Formula I′ and pharmaceutically acceptable esters or salts thereof.
Claims1
A compound of Formula I′, or a pharmaceutically acceptable salt or ester thereof:
- where:
- W is oxygen;
- X′ is —P(═O)(OR′)—, wherein R′ is a hydrogen;
- Y is —PO3R′2, wherein R′ is a hydrogen;
- R1′ is a hydroxyl (—OH);
- R2′ is chlorine (—Cl);
- and
- R3′ and R4′, together with the nitrogen atom to which they are attached, form a monocyclic, bicyclic, tricyclic, spiral-cyclic, or fused-cyclic system, wherein the cyclic system is substituted or unsubstituted.
5 more elements
Dependencies are inferred from the claim text.