Conjugates including a detectable moiety

A compound having Formula (I):

• [Z]-[Q]m-[W] (I),
• wherein
• Z is (i) a tissue reactive moiety selected from a tyramide, a tyramide derivative, or a quinone methide precursor, or (ii) a functional group or a moiety including a functional group capable of participating in a click chemistry reaction, wherein the functional group or the moiety including the functional group capable of participating in the click chemistry reaction is a dibenzocyclooctyne, a trans-cyclooctene, an alkyne, an alkene, an azide, a tetrazine, a maleimide, a N-hydroxysuccinimide, a thiol, a 1,3-nitrone, an aldehyde, a ketone, a hydrazine, a hydroxylamine, an amino group;
• Q is a branched or unbranched, linear or cyclic, substituted or unsubstituted group having between 2 and 40 carbon atoms, and optionally having one or more heteroatoms selected from O, N, or S;
• m is 0, 1, or 2;
• and
• W has Formula (VIIA):
• wherein Rx is H or a branched or unbranched C1-C4 alkyl group optionally substituted with one or more halogen atoms;
• Rm is H, a branched or unbranched C1-C4 alkyl group which is optionally substituted with one or more halogen atoms and or one or more —S(O)(O)(OH) groups, or a branched or unbranched C1-C20 alkyl group optionally including one or more heteroatoms selected from O or N, and optionally including one or more carbonyl groups, provided that the C1-C20 alkyl group terminates in a moiety capable of participating in a click chemistry reaction, wherein the moiety capable of participating in the click chemistry reaction is a dibenzocyclooctyne, a trans-cyclooctene, an alkyne, an alkene, an azide, a tetrazine, a maleimide, a N-hydroxysuccinimide, a thiol, a 1,3-nitrone, an aldehyde, a ketone, a hydrazine, a hydroxylamine, an amino group;
• Rq and Rr are each independently H, a branched or unbranched C1-C4 alkyl group optionally substituted with one or more halogen atoms, or a group Rs, where Rs is a saturated or unsaturated C1-C20 alkyl group comprising at least one amide group, and which is optionally substituted with one or more heteroatoms, provided that the group Rs terminates in a moiety capable of participating in a click chemistry reaction, wherein the moiety capable of participating in the click chemistry reaction is a dibenzocyclooctyne, a trans-cyclooctene, an alkyne, an alkene, an azide, a tetrazine, a maleimide, a N-hydroxysuccinimide, a thiol, a 1,3-nitrone, an aldehyde, a ketone, a hydrazine, a hydroxylamine, an amino group,
• provided that at least one of Rq or Rr comprises a group Rs, and further provided that Rq and Rr are both not Rs.