Substituted aminothiazoles as DGKzeta inhibitors for immune activation

A compound of formula (I):

• wherein:
• R1 is a phenyl or pyridinyl optionally substituted with one or two substituents independently selected from the group consisting of a fluorine atom, a chlorine atom, a bromine atom, cyano, difluoromethyl, trifluoromethyl, methoxy, benzyloxy, difluoromethoxy and trifluoromethoxy,
• or two substituents attached to adjacent carbon atoms of the phenyl or pyridinyl of R1 together form a bivalent group —O—CF2—O—;
• R2 is
• wherein “*” indicates the point of attachment to the nitrogen atom to which R2 is attached;
• R3 is methyl or —NH2;
• R4 is a phenyl or pyridinyl optionally substituted with one or two substituents independently selected from the group consisting of a halogen atom, C1-C2-alkyl, C1-C2-fluoroalkyl, —OR9, —N(R10)(R11), —C(═O)—N(R12)(R13), and —C(═O)—OR17;
• R7 is a hydrogen atom or a C1-C2-alkyl;
• R8 is —C(═O)—NH2;
• R9 is selected from the group consisting of a hydrogen atom, C1-C2-alkyl, benzyl, C1-C2-fluoroalkyl, (C1-C2-alkoxy)-C2-alkyl-, ((C1-C2-alkyl)-C(═O)—O)—C2-alkyl-, —C(R18)(R19)—C(═O)—N(R20)(R21), —C(═O)—N(R20)(R21) and phenyl,
• wherein the phenyl of R9 and the phenyl within the benzyl of R9 are optionally substituted with one or two substituents independently selected from the group consisting of a fluorine atom, a chlorine atom, cyano, and methyl;
• R10 and R11 are independently selected from the group consisting of a hydrogen atom, C1-C2-alkyl, (C3-C5-cycloalkyl)-(C1-C2-alkyl)-, C3-C7-cycloalkyl, and (phenyl)-(C1-C2-alkyl)-O—C(═O)—,
• wherein the C3-C7-cycloalkyl, and the C3-C5-cycloalkyl within the (C3-C5-cycloalkyl)-(C1-C2-alkyl)- of R10 and R11 are optionally substituted with one or two substituents independently selected from the group consisting of a fluorine atom, cyano, methyl, and C1-fluoroalkyl,
• and wherein the phenyl within the (phenyl)-(C1-C2-alkyl)-O—C(═O)— of R10 and R11 is optionally substituted with one or two substituents independently selected from the group consisting of a fluorine atom, a chlorine atom, and a methyl,
• or
• R10 and R11 are taken together with the nitrogen atom to which they are attached to form a monocyclic nitrogen-containing 4- to 7-membered heterocycloalkyl which is optionally substituted with one or two substituents independently selected from the group consisting of a fluorine atom, cyano, methyl, and C1-fluoroalkyl;
• R12 and R13 are independently selected from the group consisting of a hydrogen atom, C1-C4-alkyl, C1-C2-fluoroalkyl, C1-C2-hydroxyalkyl, (C1-C4-alkoxy)-C2-C3-alkyl-, (C1-C2-fluoroalkoxy)-C2-C3-alkyl-, (phenoxy)-C2-C3-alkyl-, C3-C7-cycloalkyl, and (phenyl)-(C1-C2-alkyl)-,
• wherein the C3-C7-cycloalkyl is optionally substituted with one or two substituents independently selected from the group consisting of a fluorine atom and a methyl group,
• and wherein the phenyl within the (phenoxy)-C2-C3-alkyl- and the phenyl within the (phenyl)-(C1-C2-alkyl)- are optionally substituted with one or two substituents independently selected from the group consisting of a fluorine atom, a chlorine atom, methyl, trifluoromethyl, and methoxy;
• R17 is C1-C2-alkyl;
• R18 and R19 are independently a hydrogen atom or a methyl group;
• R20 is selected from the group consisting of a hydrogen atom, C1-C3-alkyl, and phenyl,
• wherein the C1-C3-alkyl of R20 is optionally substituted with one or two substituents independently selected from the group consisting of a fluorine atom, hydroxy, C1-C3-alkoxy, and phenyl, wherein the phenyl substituent on R20 is optionally substituted with one or two substituents independently selected from the group consisting of a fluorine atom, a chlorine atom, and a methyl group,
• and wherein the phenyl of R20 is optionally substituted with one, two, or three substituents independently selected from the group consisting of a fluorine atom, a chlorine atom, methyl, trifluoromethyl, methoxy, and trifluoromethoxy, and
• R21 is a hydrogen atom or a C1-C2-alkyl,
• or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or mixture of any of the foregoing.