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US 12,673,924 B2Granted
Valiolamine derivatives as glucosidase inhibitors
AssigneeEmergent Product Development Gaithersburg Inc.
InventorsAnthony M. Treston, Kelly Lyn Warfield
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Abstract
This disclosure is directed to N-substituted valiolamine compounds, their use as glycosidase inhibitors, and in methods of treating diseases or conditions in which glycosidase inhibition provides benefit.
Claims19
A compound according to Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein
- W1-W5 are each independently selected from the group consisting of —H, benzyl, —C(═O)—C1-C9 alkyl, and —C(═O)O—C1-C9 alkyl;
- R1 is optionally substituted C1-C9 alkylene;
- R2 is absent or selected from the group consisting of —NH—, —O—, —C(═O)—, and —NH—C(═O)O—;
- R3 is absent or selected from the group consisting of —O—, —C(═O)—, —C(═O)O, and optionally substituted C1-C6 alkylene;
- R4 is —NH—;
- R5 is
- wherein
- X1, X2, X3, X4, and X5 are each independently selected from the group consisting of —H, —NO2, —N3, optionally substituted C2-C12 heterocycle, and optionally substituted C1-C12 heteroaryl.
7 more elements
Dependencies are inferred from the claim text.