# US 12,673,205 B2 · Treatment of inflammation by selective DMV cholinergic neuron stimulation

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- Number: US 12,673,205 B2
- Document ID: US12673205B2
- Status: Granted
- Kind: B2
- Application number: 18/373,673
- Filed: 2023-09-27
- Published: 2024-03-28
- Granted: 2026-07-07
- Earliest claimed: 2018-02-12
- Assignees: The Feinstein Institutes for Medical Research
- Applicants: The Feinstein Institutes for Medical Research
- Inventors: Adam M. Kressel; Valentin A. Pavlov; Sangeeta S. Chavan; Kevin J. Tracey
- Web page: https://patentgrep.com/patent/US12673205B2

## CPC

- A61N 1/36014: {External stimulators, e.g. with patch electrodes (external pacemakers A61N1/3625)}
- A61N 1/36053: {adapted for vagal stimulation (A61N1/36114 takes precedence)}
- A61N 1/0412: {Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs}
- A61N 1/0456: {Specially adapted for transcutaneous electrical nerve stimulation [TENS]}
- A61N 1/0536: {Preventing neurodegenerative response or inflammatory reaction}
- A61N 1/3615: {Intensity}
- A61N 5/067: using laser light
- A61N 1/0504: {Subcutaneous electrodes}
- A61N 5/0622: {Optical stimulation for exciting neural tissue}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

Methods for electrical modulation of inflammation or serum TNF levels in a subject.

## Claims

### Claim 1

A method of artificially increasing splenic norepinephrine release in a subject comprising selectively artificially electrically stimulating cholinergic neurons in a dorsal motor nucleus of a vagal nerve of the subject, wherein no other source of vagal nerve activity is artificially electrically stimulated, effective to increase splenic norepinephrine release.

### Claim 2 (depends on 1)

The method of claim 1, wherein the subject is human.

### Claim 3 (depends on 1)

The method of claim 1, wherein the subject has sepsis or is developing sepsis.

### Claim 4 (depends on 1)

The method of claim 1, wherein the subject has endotoxemia, septicemia or septic shock.

### Claim 5 (depends on 1)

The method of claim 1, wherein electrically stimulating is effected using microelectrodes placed in the subject's central nervous system.

### Claim 6 (depends on 5)

The method of claim 5, wherein the microelectrodes are positioned stereotactically prior to electrical stimulation.