Bladder, ureter, kidney, urethra, prostate and catheter anti-microbial, and biofilm prevention, reduction and treatment
AssigneeUhi, LLC
InventorsKristina Albert, Carmen Fonseca, Afif Ghannoum
Life of this patent
Estimating the term…
Abstract
A method for preventing and treating internal infections, e.g., urinary tract infections, caused by catheters is provided, in particular by reduction in catheter-associated biofilms. A coating composition is used to treat the catheter and applied through the catheter into the bladder or other body urinary tract organ to kill or neutralize microorganisms, including biofilms therein. The composition comprises a humectant and an antimicrobial with the antimicrobial including a monoquaternary ammonium compound or pharmaceutically acceptable salt thereof. The coating layer has antimicrobial cidal or static activity for at least about one hour.
Claims20
A method for preventing or treating a urinary system infection, comprising the steps of:
- instilling through a catheter an antimicrobial coating composition into a urinary system of a mammal;
- the antimicrobial coating composition comprising:
- about 0.07%≤H≤about 70%;
- and
- about 0.0005%<A
- wherein all percentages are by weight of the total composition;
- wherein H is a humectant;
- and A is an antimicrobial agent;
- the antimicrobial agent comprising a monoquaternary ammonium compound or pharmaceutically acceptable salt thereof;
- trapping, and neutralizing or killing harmful microorganisms in the urinary system or reducing or killing a biofilm in the urinary system;
- wherein the antimicrobial coating composition dwells in a bladder or urinary tract for 5 sec to 1 hour before removing the antimicrobial coating composition from the bladder or urinary tract.
A method for treating a urinary tract catheter or tubing system comprising:
- moving a bolus of a first antimicrobial coating composition through tubing and equipment coupled to a catheter;
- wherein an interior of the tubing is contacted with a flow or a static presence of the composition for 5 seconds to 60 minutes;
- wherein the first antimicrobial coating composition comprises:
- about 0.07%≤H≤about 70%;
- and
- about 0.0005%<A;
- wherein all percentages are by weight of the total composition;
- wherein H is a humectant;
- and A is an antimicrobial agent;
- wherein the antimicrobial agent comprises a monoquaternary ammonium compound or pharmaceutically acceptable salt thereof;
- wherein the antimicrobial coating composition dwells in a bladder or urinary tract for 5 sec to 1 hour before removing the antimicrobial coating composition from the bladder or urinary tract.
A method for preventing, reducing or treating catheter-associated urinary tract infections in a urinary tract of a mammal, comprising:
- applying a first coating of a first antimicrobial composition on an interior of a catheter, an exterior of the catheter, or both the interior and exterior of the catheter;
- applying a second coating on a lining of a bladder of the mammal by instilling through the catheter a second antimicrobial composition into a bladder or kidney of a mammal;
- in the first coating and the second coating, killing or neutralizing microorganisms encountered on a surface of the catheter or a surface of the bladder or kidney or encountered from an environment after the applying steps are performed;
- and
- the composition comprising a monoquaternary ammonium compound or pharmaceutically acceptable salt thereof;
- wherein the first and second coating are different;
- wherein the first or second antimicrobial coating composition dwells in a bladder or urinary tract for 5 sec to 1 hour before removing the first or second antimicrobial coating composition from the bladder or urinary tract;
- wherein the first and second antimicrobial compositions are different and independently comprise:
- about 0.07%≤H≤about 70%;
- and
- about 0.001%≤A≤about 5%;
- wherein all percentages are by weight of the total composition;
- wherein H is a humectant;
- and A is an antimicrobial agent.
Dependencies are inferred from the claim text.