Back to results
US 12,673,139 B2Granted
3D printed UV crosslinking masks
AssigneeUniversity of Maryland, College Park
InventorsMegan Kimicata, John Patrick Fisher
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeUniversity of Maryland, College Park
InventorsMegan Kimicata, John Patrick Fisher
Estimating the term…
Current approaches in small diameter vascular grafts for coronary artery bypass surgeries fail to address physiological variations along the graft that contribute to thrombus formation and ultimately graft failure. An interlayer drug delivery system can sustain delivery of heparin through the graft with a high degree of temporal and spatial control. A heparin-loaded gelatin methacrylate interlayer sits between a biohybrid composed of decellularized bovine pericardium and poly(propylene fumarate) and UV crosslinking is controlled via 3D printed shadow masks. The masks enable control of the resultant gelMA crosslinking and properties by modulating the incident light intensity on the graft. High doses of heparin have detrimental effects on endothelial cell function. When exposed to heparin in a slower, more sustained manner consistent with the masks, endothelial cells behave similarly to untreated cells. Slower release profiles cause significantly more release of tissue factor pathway inhibitor, an anticoagulant, than a faster release profile.
A method to control localized drug delivery to elicit a cell response, the method comprising:
A method to control localized drug delivery to elicit a cell response, the method comprising:
A method to control localized drug delivery to elicit a cell response, the method comprising:
Dependencies are inferred from the claim text.