US 12,673,132 B2 · Extrusion printing of biocompatible scaffolds

Abstract

Compositions and methods for making biocompatible articles are provided. A method includes preparing a 3D printable mixture and depositing successive layers of the mixture in a predetermined pattern to form a porous biocompatible article. The predetermined pattern has a porosity suitable for a bone or cartilage scaffold. Associated 3D printable compositions and porous articles made from the described methods are also described. The preparing a 3D printable mixture can comprise conjugating an alkyne-terminated polymer to a peptide to form a peptide-containing composite, or providing a mixture that comprises a ceramic material and a binder, and wherein the 3D printable mixture comprises from 50 wt. % to 80 wt. % of the ceramic material.

Claims27

Dependent claims

A method of making a biocompatible article comprising:

preparing a 3D-printable mixture, wherein the preparing comprises conjugating an alkyne-terminated polymer to a peptide to form a peptide-containing composite, and wherein the peptide is a tissue-specific bioactive peptide selected from the group consisting of an osteogenic bone morphogenetic protein mimetic peptide comprising a peptide having the sequence of SEQ ID NO:1, an osteogenic glycine-histidine-lysine peptide comprising a peptide having the sequence of SEQ ID NO:2 or SEQ ID NO:4, a chondrogenic N-cadherin peptide comprising a peptide having the sequence of SEQ ID NO:3 or SEQ ID NO;5, and combinations thereof;
and
depositing successive layers of the mixture in a predetermined pattern to form a porous biocompatible article,
wherein the predetermined pattern comprises a porosity suitable for a bone or cartilage scaffold.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

17/904,266Filed 2 Feb 2021 · us provisional application

Priority

14 Feb 2020

Published

US 2023/0091323 A123 Mar 2023

Granted

7 Jul 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification48 codes

A61L 27/18
Macromolecular materials: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
B33Y 80/00
Products made by additive manufacturing
A61F 2/08
Prostheses implantable into the body: muscles; Tendons; Ligaments
A61F 2/2846
Bones: support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects

Extrusion printing of biocompatible scaffolds

Life of this patent

Extrusion printing of biocompatible scaffolds

Life of this patent

Abstract

Claims27