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US 12,673,119 B2Granted
Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
AssigneeUniversity of Rochester
InventorSteven A. Goldman
Life of this patent
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Abstract
The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model to identify agents suitable for treating a neurodegenerative disorder. The present application also relates to methods of treating neurodegenerative disorders and restoring normal brain interstitial potassium levels.
Claims8
A method of restoring normal brain interstitial K + levels in a subject with dysregulated glial K + channel function, said method comprising:
- selecting a subject having dysregulated K + channel function;
- and administering to the selected subject a preparation of glial progenitor cells that are both CD140a+ and CD44+ at a dosage effective to restore normal brain interstitial glial K + levels in the selected subject.
Dependencies are inferred from the claim text.