Methods and compositions for treating cancer with cancer-targeted adjuvants
AssigneeThe University of Chicago
InventorsJeffrey A. Hubbell, David S. Wilson, Tiffany M. Marchell, Laura T. Gray
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Abstract
Here, the inventors describe methods and compositions for targeting a TLR agonist to the tumor cell or stroma. Aspects of the disclosure relate to a polypeptide comprising a tumor targeting agent operatively linked to p(Man-TLR). Also disclosed are compositions and methods for treating cancer in a subject comprising administration of the polypeptide comprising the tumor targeting agent linked to p(Man-TLR) to the subject.
Claims11
A method for treating cancer, for targeting a TLR agonist to a tumor in a subject, or for increasing the accumulation of a TLR agonist in a tumor in a subject, the method comprising administering a polypeptide comprising a collagen binding domain covalently linked to p(Man-TLR7), wherein the collagen binding domain comprises:
- the amino acid sequence of one of SEQ ID NOS:
- 1, 2, or 8.
A method for treating melanoma in a subject, the method comprising administering a polypeptide comprising a collagen binding domain covalently linked to p(Man-TLR7), wherein the collagen binding domain comprises the amino acid sequence of one of SEQ ID NOS:
- 1, 2, or 8.
Dependencies are inferred from the claim text.