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US 12,673,089 B2Granted
Methods for treating osteoarthritis
AssigneesPresident and Fellows of Harvard College, The Salk Institute for Biological Studies
InventorsPaloma Martinez Redondo, Isabel Guillen-Guillen, Juan Carlos Izpisua Belmonte, Noah Davidsohn, George M. Church, Pedro Guillen Garcia
Life of this patent
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Abstract
Methods are provided for treating osteoarthritis by administering αKlotho protein and sTGFβ-R2 protein to a site within a mammal exhibiting symptoms of osteoarthritis, such as a knee joint. The αKlotho protein and the sTGFβ-R2 protein are both present at the osteoarthritic site.
Claims24
A method of treating osteoarthritis in a subject in need thereof, the method comprising administering to the subject:
- (i) a first viral vector comprising a first nucleic acid sequence encoding a soluble Transforming Growth Factor Beta Receptor II (sTGFβ-R2) protein and a second nucleic acid sequence encoding an αKlotho protein, optionally wherein the first nucleic acid sequence and second nucleic acid sequence are operably linked via a polycistronic element;
- or
- (ii) a first viral vector comprising a first nucleic acid sequence encoding a soluble Transforming Growth Factor Beta Receptor II (sTGFβ-R2) protein and a second viral vector comprising a second nucleic acid sequence encoding an αKlotho protein.
Dependencies are inferred from the claim text.