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US 12,673,078 B2Granted
Bacteriophages producing heterologous bacteriocins
AssigneeETH Zurich
InventorsSamuel Nando Kilcher, Matthew Stephen Dunne, Susanne Andrea Meile, Jiemin Du, Martin Johannes Loessner
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Abstract
The present invention relates to the field of medicine, specifically the field of bacterial infection and treatment thereof.
Claims13
A modified bacteriophage capable of infecting a host bacterium, wherein the bacteriophage genome comprises a gene that is foreign to the bacteriophage, wherein said gene encodes a bacteriocin selected from the group consisting of Colicin M as set forth in SEQ ID NO:
- 18, Colicin E7 as set forth in SEQ ID NO:
- 20, Colicin K as set forth in SEQ ID NO:
- 19, Colicin 5 as set forth in SEQ ID NO:
- 17, Colicin E6 as set forth in SEQ ID NO:
- 16 and Klebicin M as set forth in SEQ ID NO:
- 21, while maintaining its wild-type bacteriocin functionality.
3 more elements
Dependencies are inferred from the claim text.