Encapsulated cells expressing IL-12 and uses thereof
AssigneeWilliam Marsh Rice University
InventorsOmid Veiseh, Amanda Nash, Samira Aghlara-Fotovat
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Abstract
The present disclosure relates to implantable constructs (encapsulated cells) designed to deliver therapeutic reagents, such as IL-12 and/or IL-12 and methods of using the same to treat conditions, such as cancer.
Claims18
A population of encapsulated cells comprising a plurality of oligonucleotide molecules encoding a IL-12 polypeptide, wherein the native human IL-12 polypeptide is a heterodimeric complex comprising a native human IL-12 (p35) polypeptide and a native human IL-12 (p40) polypeptide, further wherein the IL-12 (p35) polypeptide and the IL-12 (p40) polypeptide is expressed at a ratio (IL-12 (p35):IL-12 (p40)) of about 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, or 1:10.
Dependencies are inferred from the claim text.