Antimycotic methoxyflavone and fluconazole combination for inhibiting cryptococcus
AssigneeKarl-Franzens-Universität Graz
InventorsKatharina Kainz, Andreas Zimmermann, Didac Carmona-Gutierrez, Frank Madeo
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Abstract
The present invention relates to methods and means for inhibiting or preventing the growth of fungal cells with at least one flavone selected from the group consisting of 5-methoxyflavone, 2′-methoxyflavone, 7-methoxyflavone, 3′,4′,5,7-tetrametoxyflavone, 3′,4′,5′,5,6,7-hexymethoxyflavone, 7,8-benzoflavone and 5,6-benzoflavone for inhibiting or preventing the growth of a fungal cell, wherein said flavone is used in combination with at least one further antimycotic compound selected from the group of azoles, both in an amount to exhibit a synergistic effect compared to the separate use of said flavone and said antimycotic compound.
Claims12
A method of for inhibiting or preventing the growth of a fungal cell selected from the group consisting of Cryptococcus fungi, the method comprising contacting fungal cells with 5-methoxyflavone, in combination with fluconazole, both in an amount to exhibit a synergistic effect compared to the separate use of said 5-methoxyflavone and said fluconazole.
A method for treating a fungal infection in a human or animal caused by a fungus selected from the group consisting of Cryptococcus fungi, the method comprising administering to the human or animal of 5-methoxyflavone, wherein the 5-methoxyflavone is administered to the human or animal together or subsequently with fluconazole-2′ methoxyflavone.
A method for inhibiting or preventing the growth of a fungal cell comprising the step of contacting fungal cells with a composition comprising 5-methoxyflavone and fluconazole, both in an amount to exhibit a synergistic effect compared to the separate use of said 5-methoxyflavone and said fluconazole, with the proviso that the fungal cells are not C. albicans.
Dependencies are inferred from the claim text.