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US 12,673,014 B2Granted
Inhibitors of glycosphingolipid synthesis and methods of use
AssigneeChatterjee Subroto
InventorSubroto B. Chatterjee
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Abstract
Compositions in the prevention and treatment of skin diseases or associated disorders, inflammation or inflammatory diseases or disorders, include at least one inhibitor of glycosphingolipid synthesis.
Claims8
A method of treating hair loss or alopecia comprising:
- orally or topically administering to a subject in need thereof a composition comprising a therapeutically effective amount of an encapsulated inhibitor of glycosphingolipid synthesis inhibitor,
- wherein the glycosphingolipid synthesis inhibitor is D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP);
- wherein the D-PDMP is encapsulated in a polyethylene glycol-sebacic acid polymer;
- and wherein the effective amount is a dose amount of 1 mg to 10 mg of D-PDMP per kg of subject body weight.
1 more element
A method of treating hair discoloration comprising:
- orally or topically administering to a subject in need thereof a composition comprising a therapeutically effective amount of an encapsulated inhibitor of glycosphingolipid synthesis inhibitor,
- wherein the glycosphingolipid synthesis inhibitor is D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP);
- wherein the D-PDMP is encapsulated in a polyethylene glycol-sebacic acid polymer;
- and wherein the effective amount is a dose amount of 1 mg to 10 mg of D-PDMP per kg of subject body weight.
1 more element
Dependencies are inferred from the claim text.