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US 12,672,781 B2Granted
Systems and methods for imaging using a configurable platform
AssigneeStryker Corporation
InventorsJohn Josef Paul Fengler, Robert Anthony Stead
Life of this patent
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Abstract
Provided herein are systems for fluorescence imaging of an object and methods of use thereof, the systems comprising: an image sensor assembly comprising at least one image sensor; and an optical assembly configured to transmit light emitted from the object to the image sensor assembly, the optical assembly comprising at least one notch filter configured to block light in a plurality of fluorescence excitation wavebands while transmitting fluorescence light that is emitted from the object, wherein the optical assembly is configured to project the emitted fluorescence light as one or more fluorescence images onto the at least one image sensor of the image sensor assembly.
Claims31
A system for fluorescence imaging of an object, comprising:
- an image sensor assembly comprising at least one image sensor;
- and
- an illuminator configured to emit excitation light in a plurality of excitation wavebands for causing the object to emit fluorescence light, wherein the plurality of excitation wavebands comprises a plurality of visible light wavebands, the illuminator comprising:
- at least one first fluorescence excitation light emitter configured to emit fluorescence excitation light having a first waveband of the plurality of visible light wavebands,
- at least one second fluorescence excitation light emitter configured to emit fluorescence excitation light having a second waveband of the plurality of visible light wavebands, the second waveband being different than the first waveband, wherein the illuminator is configured to activate the at least one first fluorescence excitation light emitter independently of the at least one second fluorescence excitation light emitter, and
- at least one imaging light emitter configured to emit imaging light for reflected light imaging of the object;
- and
- an optical assembly configured to transmit imaging light reflected from the object and fluorescence light emitted from the object to the image sensor assembly, the optical assembly comprising at least one notch filter configured to block light in the plurality of fluorescence excitation wavebands while transmitting the fluorescence light and imaging light reflected from the object that is not in the plurality of fluorescence excitation wavebands,
- wherein the optical assembly is configured to project the fluorescence light and the imaging light reflected from the object that is not in the plurality of fluorescence excitation wavebands onto the at least one image sensor of the image sensor assembly, wherein at least a portion of the fluorescence light and at least a portion of the imaging light reflected from the object that is not in the plurality of fluorescence excitation wavebands are projected onto the same image sensor of the image sensor assembly.
6 more elements
A method for fluorescence imaging, comprising:
- generating, by at least one first fluorescence excitation light emitter of an illuminator of an imaging system, light in a first excitation waveband to cause a first fluorescence light emission from a first target, wherein the first excitation waveband is a first visible light waveband;
- blocking, by at least one notch filter of the imaging system, the light in the first excitation waveband while transmitting the first fluorescence light emission to at least one image sensor of the imaging system;
- generating, by at least one second fluorescence excitation light emitter of the illuminator, light in a second excitation waveband to cause a second fluorescence light emission from a second target, wherein the second excitation waveband is a second visible light waveband, the second waveband being different than the first waveband, and wherein activation of the at least one second fluorescence excitation light emitter is independent of activation of the at least one first fluorescence excitation light emitter;
- blocking, by the at least one notch filter of the imaging system, the light in the second excitation waveband while transmitting the second fluorescence light emission to the at least one image sensor of the imaging system;
- generating, by an imaging light emitter of the illuminator, imaging light that reflects from the first target;
- and
- transmitting, by the at least one notch filter of the imaging system, the imaging light reflected from the first target that is not in the first excitation waveband or in the second excitation waveband onto the at least one sensor of the imaging system, wherein at least a portion of the first fluorescence light emission and at least a portion of the imaging light reflected from the first target that is not in the first excitation waveband or in the second excitation waveband are projected onto the same image sensor of the imaging system.
4 more elements
Dependencies are inferred from the claim text.