Method for memory B cell-specific differentiation induction, and uses thereof
AssigneeKorea Research Institute of Bioscience and Biotechnology
InventorsJung Joo Hong, Green Kim, Hanseul Oh, Bon Sang Koo, Seung Ho Baek, Phil Yong Kang, Eun Ha Hwang
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method for memory B cell-specific differentiation induction and to uses thereof and, more specifically, to an anti-CD3 antibody or ligand in a biological sample obtained from and individual, a method for memory B cell-specific differentiation induction comprising a step of treating an anti-CD28 antibody or ligand, and a method for detection a memory B cell which is specific to a specific antigen by using same.
Claims10
A method for detecting antigen-specific memory B cells in a subject that may have been infected with viruses or bacteria comprising the steps of:
- (a) contacting a biological sample obtained from the subject with an anti-CD3 antibody or ligand, and an anti-CD28 antibody or ligand, wherein the biological sample comprises memory B cells and wherein the anti-CD3 antibody or ligand and the anti-CD28 antibody or ligand induce the differentiation of the memory B cells;
- (b) contacting the biological sample of step (a) with an antigen;
- and
- (c) detecting an antibody that is secreted by the antigen-specific memory B cells in the biological sample and that specifically binds to the antigen of step (b) wherein the antigen is expressed by the viruses or bacteria which may have infected the subject.
A method for specifically inducing differentiation of memory B cells comprising:
- contacting a biological sample obtained from a subject with an anti-CD3 antibody or ligand, and an anti-CD28 antibody or ligand, wherein the biological sample comprises the memory B cells in a subject that may have been infected with viruses or bacteria.
Dependencies are inferred from the claim text.