Size-tunable synthetic particles with tunable optical properties and methods for using the same for immune cell activation
AssigneeSlingshot Biosciences, Inc.
InventorsDaixuan Zhang, Solomon Stonebloom, Juan Armas, Harini Kethar, Sunil Thomas, Martina De Geus
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Abstract
A hydrogel particle, comprising a matrix comprising a polymerized monomer, said matrix comprising a plurality of micropores and a plurality of macropores, and one or more immunostimulatory biomolecules selected from the group consisting of an anti-CD3 antibody or antigen-binding fragment thereof, an anti-CD28 antibody or antigen-binding fragment thereof, and combinations thereof.
Claims78
A particle for inducing an immune cell response, the particle comprising:
- a matrix comprising a polymerized monomer having a plurality of micropores and a plurality of macropores;
- and
- one or more immunostimulatory or co-stimulatory biomolecules,
- wherein the plurality of macropores comprise an average diameter between about 200 nm and about 2 μm, wherein the particle is capable of inducing the immune cell response when contacted with an immune cell, and wherein the immune cell response comprises activation and/or expansion of the immune cell.
A particle for inducing an immune cell response, the particle comprising:
- a matrix comprising a polymerized monomer having a plurality of micropores and a plurality of macropores;
- and
- one or more immunostimulatory or co-stimulatory biomolecules,
- wherein the particle is capable of inducing the immune cell response when contacted with an immune cell, wherein the immune cell response comprises activation and/or expansion of the immune cell, and wherein the immune cell response from contacting the immune cell with the particle is higher than the immune cell response from a control immune cell contacted with an otherwise identical particle lacking the plurality of macropores.
A particle for inducing an immune cell response, the particle comprising:
- a matrix comprising a polymerized monomer having a plurality of micropores and a plurality of macropores;
- and
- one or more immunostimulatory or co-stimulatory biomolecules,
- wherein the particle is capable of inducing the immune cell response when contacted with an immune cell, wherein the immune cell response comprises activation and/or expansion of the immune cell, and wherein the plurality of micropores are formed during monomer polymerization.
A particle for inducing an immune cell response, the particle comprising:
- a matrix comprising a polymerized monomer having a plurality of micropores and a plurality of macropores;
- and
- one or more immunostimulatory or co-stimulatory biomolecules,
- wherein the particle is capable of inducing the immune cell response when contacted with an immune cell, wherein the immune cell response comprises activation and/or expansion of the immune cell, and wherein the particle has a diameter of between about 1 μm and about 25 μm.
Dependencies are inferred from the claim text.