Back to results
US 12,668,835 B1Granted
Substrate holder
Assignee10x Genomics, Inc.
InventorsAugusto Manuel Tentori, Rajiv Bharadwaj
Life of this patent
Estimating the term…
Abstract
A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.
Claims30
A device comprising:
- a first substrate comprising one or more first lateral surfaces;
- a second substrate comprising one or more second lateral surfaces;
- a first support member comprising a first planar surface configured to support the first substrate;
- a first retaining mechanism comprising a first recess and a first retaining member, wherein the first recess is formed in the first support member and is configured to receive the first substrate and the first retaining member is configured to apply a first force to the one or more first lateral surfaces of the first substrate;
- a second support member comprising a second planar surface configured to support the second substrate;
- a second retaining mechanism configured to receive the second substrate, the second retaining mechanism comprising a second retaining member configured to apply a second force to the one or more second lateral surfaces of the second substrate;
- an alignment mechanism comprising a rotating actuator operably connecting the first support member and the second support member;
- and
- a spacing member connected to the first support member or to the second support member,
- wherein the first support member and the second support member have an open configuration and a closed configuration,
- wherein the rotating actuator is configured to bring the first planar surface and the second planar surface toward one another from the open configuration to the closed configuration by enabling a relative movement of the first support member and the second support member, and
- wherein, in the closed configuration:
- the first planar surface is parallel to and opposite the second planar surface;
- and
- the spacing member is in contact with the first support member and with the second support member such that the first planar surface is disposed at a distance from the second planar surface.
12 more elements
A device comprising:
- a first support member comprising a first planar surface configured to support a first substrate;
- a first retaining mechanism comprising a first recess and a first retaining member, wherein the first recess is formed in the first support member and is configured to receive the first substrate and the first retaining member is configured to apply a first force to one or more first lateral surfaces of the first substrate;
- a second support member comprising a second planar surface configured to support a second substrate;
- a second retaining mechanism comprising a second retaining member configured to apply a second force to one or more second lateral surfaces of the second substrate;
- an alignment mechanism comprising:
- a rotating actuator operably connecting the first support member and the second support member, wherein the rotating actuator comprises one or more arms operably connecting the first support member and the second support member and an arm of the one or more arms comprises an internal pivoting mechanism;
- and
- a plurality of connectors positioned on the first support member;
- and
- a plurality of receivers positioned on the second support member, wherein the plurality of connectors are arranged to engage with the plurality of receivers to align the first support member and the second support member;
- and
- a spacing member connected to the first support member or to the second support member,
- wherein the first support member and the second support member have an open configuration and a closed configuration,
- wherein the rotating actuator is configured to bring the first planar surface and the second planar surface toward one another from the open configuration to the closed configuration by enabling a relative movement of the first support member and the second support member, and
- wherein, in the closed configuration:
- the first planar surface is parallel to and opposite the second planar surface;
- and
- the spacing member is in contact with the first support member and with the second support member such that the first planar surface is disposed at a distance from the second planar surface.
15 more elements
Dependencies are inferred from the claim text.