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US 12,668,823 B2Granted
Microorganism having increased activity of 3-methyl-2-oxobutanoate hydroxymethyltransferase, and use thereof
AssigneeCj Cheiljedang Corporation
InventorsKwang Soo Shin, Kwang Woo Lee, Yee-Seul So, Yeon-Jae Jang, Jihyun Shim
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Abstract
Provided are: a polypeptide having activity of 3-methyl-2-oxobutanoate hydroxymethyltransferase; a microorganism having increased activity of 3-methyl-2-oxobutanoate hydroxymethyltransferase; a composition for producing pantothenic acid and/or pantoic acid, comprising the polypeptide and/or the microorganism, and a pantothenic acid and/or pantoic acid production method comprising a step for culturing the microorganism.
Claims9
A polypeptide comprising an amino acid sequence having at least 90% identity to the amino acid sequence of SEQ ID NO:
- 37, wherein the amino acid corresponding to position 116 of the amino acid sequence of SEQ ID NO:
- 37 is substituted with alanine (A, Ala), asparagine (N, Asn), threonine (T, Thr), glutamic acid (E, Glu), serine (S, Ser), valine (V, Val), isoleucine (I, Ile), leucine (L, Leu), aspartic acid (D, Asp), or cysteine (C, Cys).
- wherein the polypeptide has an activity of 3-methyl-2-oxobutanoate hydroxymethyltransferase.
Dependencies are inferred from the claim text.