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US 12,668,817 B1Granted
Recombinant adeno-associated viral vectors for delivering a therapeutic gene to lungs
AssigneeTelomere Therapeutics S.L.
InventorsLindsey Plasschaert, Marta Gabasa-Ferrandez
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Abstract
The present invention provides a recombinant adeno-associated virus (rAAV) particle of 6.2 serotype comprising a recombinant nucleic acid comprising a lung-specific SpB promoter and a therapeutic gene, wherein the lung-specific promoter comprises SEQ ID NO: 1, and wherein said promoter is operably linked to and regulates the expression of the therapeutic gene.
Claims17
A recombinant adeno-associated virus (rAAV) particle comprising:
- a) a recombinant nucleic acid comprising a lung-specific SpB promoter and a therapeutic gene, wherein the lung-specific SpB promoter comprises SEQ ID NO:
- 1, and wherein the lung-specific SpB promoter is operably linked to the therapeutic gene, and
- b) an AAV capsid of 6.2 serotype.
Dependencies are inferred from the claim text.