Anti-apoptotic vector and method of using the same
AssigneeWisconsin Alumni Research Foundation
InventorsRobert W. Nickells, Gillian McLellan, Ryan J. Donahue
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Abstract
The present invention provides vectors for delivery of an anti-apoptotic therapy. The vectors include a phosphoglycerate kinase (Pgk) promoter operably connected to a polynucleotide encoding an anti-apoptotic BCL2 protein (e.g., BCLXL). The vectors may be used in methods of treating conditions associated with apoptosis, including glaucoma.
Claims20
A method of treating a subject having a condition associated with apoptosis of a cell, the method comprising administering a therapeutically effective amount of a vector to the subject, wherein the vector comprises a phosphoglycerate kinase (Pgk) promoter operably connected to a polynucleotide encoding an anti-apoptotic BCL2 protein, wherein the Pgk promoter comprises SEQ ID NO:
- 1, SEQ ID NO:
- 2, or a sequence having 90% identity to SEQ ID NO:1 or SEQ ID NO:2.
Dependencies are inferred from the claim text.