Nucleic acid drug suppressing production of myostatin gene MRNA
AssigneesKnc Laboratories Co., Ltd., National University Corporation Kobe University
InventorsMasafumi Matsuo, Kazuhiro Maeta
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Abstract
An antisense oligonucleotide of 15-30 bases or a salt or a solvate thereof, wherein the antisense oligonucleotide has a nucleotide sequence complementary to a target site in exon 1 of the myostatin gene and is capable of inhibiting the production of the mRNA of the myostatin gene. A pharmaceutical drug, a food, a feed, an agent for promoting myocyte proliferation and/or hypertrophy, an agent for increasing muscle mass and/or inhibiting muscle weakness, an agent for inhibiting production of the mRNA of the myostatin gene, and an inhibitor of the function of myostatin, each of which comprises the above antisense oligonucleotide or a salt or a solvate thereof.
Claims23
An antisense oligonucleotide or a salt or a solvate thereof, wherein the antisense oligonucleotide has a nucleotide sequence complementary to a target site in exon 1 of the myostatin gene and is capable of inhibiting the production of mRNA of the myostatin gene by inhibiting splicing of the myostatin gene,
- wherein the antisense oligonucleotide has 18 bases, and
- wherein the nucleotide sequence of the antisense oligonucleotide is any one of the sequences set forth in SEQ ID NOs:
- 3, 7, 8, 9, 10, 11, 12, 13, 18 and 24 (wherein “t” may be “u”, and “u” may be “t”).
Dependencies are inferred from the claim text.