Unglycosylated lysostaphin variant protein
AssigneeTrustees of Dartmouth College
InventorsKarl E. Griswold, Hongliang Zhao
Life of this patent
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Abstract
Unglycosylated lysostaphin variant protein, nucleic acid molecule, vector and host cell, as well as a method for production of unglycosylated lysostaphin variant protein in a yeast expression system are provided. The proteins are produced in a Pichia pastoris expression system and have been shown to have activity equivalent to wild-type lysostaphin. The lysostaphin variant proteins can be used as therapeutic proteins for treatment of diseases such as Staphylococcus aureus infection.
Claims9
A method for inhibiting growth of bacteria, the method comprising contacting the bacteria with an effective amount of a lysostaphin (LST) variant protein comprising the amino acid sequence SEQ ID NO:
- 4 or SEQ ID NO:
- 6, wherein the contacting inhibits growth of the bacteria.
An isolated unglycosylated lysostaphin variant protein comprising the amino acid sequence of SEQ ID NO:
- 4 or SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.