Monoglycerol acrylate based polymer and uses thereof

An amphiphilic poly(monoglycerol acrylate) (PMGA) polymer, comprising

• an hydrophilic repeating unit of monoglycerol acrylate;
• and
• one or more biodegradable hydrophobic group;
• wherein the polymer is a comb polymer having an average molecular weight (Mw) ranging between 1000 and 15000, ranging between 1800 and 12000, of about 1800, of about 6500, or of about 12000;
• wherein the Mw of the at least one biodegradable hydrophobic group represents at least 5%, at least 10%, at least 30%, between 5% and 30%, between 10% and 30%, about 5%, about 10% or about 30% of the average Mw of the polymer;
• and wherein the PMGA polymer is of Formula (I):
• wherein n is an integer between 10 and 80, between 30 and 50, between 40 and 50, or about 42;
• X is —(CH2)m— with m between 0 and 4;
• R1 is a donor group or R1 is halogen, —H, —OH, —SH, —S(C═S)S—C6-10aryl, —S(C═S)S—C1-24alkyl, —S(C═S)C1-24alkyl, or —S(C═S)Ph;
• Y is —OH, —COOH, —OR6, —COO(CH2)LNR2R3 or —CONR2R3 with L between 1 and 18;
• R2 and R3 are each independently —H, C6-10aryl, C3-12cycloalkyl, steroidyl groups, C3-24alkyl, C3-24alkenyl or C3-24alkynyl;
• R4 and R5 are each independently —H, —CH3 or —CN;
• and
• R6 is (CH2)L′CH3, or (CH2)L′NR2R3 with L′ between 0 and 18.