Cross-linking compounds and methods of use thereof
AssigneeNorth Carolina State University
InventorsJonathan S. Lindsey, Hikaru Fujita, Nobuyuki Matsumoto
Life of this patent
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Abstract
Compounds comprising a cross-linking moiety and a protecting group are described herein along with their methods of use. The cross-linking moiety may comprise an indoxyl and the protecting group may comprise a sugar (e.g., a glucuronide or glucoside), phosphoester, or sulfoester group. The cross-linking moiety and protecting group may be attached to each other via an oxygen atom, sulfur atom, or linker. In some embodiments, the linker attaching the cross-linking moiety and protecting group is a self-immolative linker. A compound of the present invention may cross-link under physiological conditions and/or in vivo.
Claims15
A compound having a structure of Formula I:
- wherein:
- Z is each independently a hydroxyl, amino, enzyme, polyiodide binding matrix, a targeting agent, a circulation enhancing agent, water solubilizing group, chromophore, or bioconjugatable group;
- L is a linker that comprises a polyethylene glycol;
- X1 is absent, —O—, or —S—;
- each R1 is independently selected from a halogen, alkyl, alkenyl, alkynyl, —OH, alkoxy, acyloxy, carboxy, carboxylic ester, boronate ester, thioalkoxy, and amino;
- each R2 is independently —CH2OH or —C(O)OH;
- each X2 is independently —O—, —S—, or a self-immolative linker;
- p is an integer of 1 to 6;
- b is an integer of 1 to 6;
- and
- each n is independently an integer of 1 to 4;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.