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US 12,668,645 B2Granted
Antigen binding polypeptides, antigen binding polypeptide complexes and methods of use thereof
AssigneeModeX Therapeutics, Inc.
InventorsRonnie Rong Wei, Ling Xu, Zhi-Yong Yang, Edward Seung, Gary J. Nabel
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Abstract
Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells; chimeric antigen receptors (CARs); immune cells; pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.
Claims26
A polypeptide having at least 95% identity to any one of SEQ ID NOs:
- 30 and 32-43;
- wherein the polypeptide comprises the sequences of:
- (i) a heavy chain complementarity determining region (CDR) 1 comprising the sequence of SEQ ID NO:
- 64;
- a heavy chain CDR2 comprising the sequence of SEQ ID NO:
- 65;
- a heavy chain CDR3 comprising the sequence of SEQ ID NO:
- 66;
- a light chain CDR1 comprising the sequence of SEQ ID NO:
- 67;
- a light chain CDR2 comprising the sequence of SEQ ID NO:
- 68;
- and a light chain CDR3 comprising the sequence of SEQ ID NO:
- 69;
- (ii) a heavy chain CDR1 comprising the sequence of SEQ ID NO:
- 82;
- a heavy chain CDR2 comprising the sequence of SEQ ID NO:
- 83;
- a heavy chain CDR3 comprising the sequence of SEQ ID NO:
- 84;
- a light chain CDR1 comprising the sequence of SEQ ID NO:
- 85;
- a light chain CDR2 comprising the sequence of SEQ ID NO:
- 86;
- and a light chain CDR3 comprising the sequence of SEQ ID NO:
- 87;
- and
- (iii) a heavy chain CDR1 comprising the sequence of SEQ ID NO:
- 88;
- a heavy chain CDR2 comprising the sequence of SEQ ID NO:
- 89;
- a heavy chain CDR3 comprising the sequence of SEQ ID NO:
- 90;
- a light chain CDR1 comprising the sequence of SEQ ID NO:
- 91;
- a light chain CDR2 comprising the sequence of SEQ ID NO:
- 92;
- and a light chain CDR3 comprising the sequence of SEQ ID NO:
- 93.
36 more elements
Dependencies are inferred from the claim text.